MAPPING PROTEIN INTERACTIONS BETWEEN RABIES VIRUS AND ITS HUMAN HOSTAbstract
Rabies is a fatal viral disease which is caused by negative sense, single-stranded RNA virus belonging to Rhabdoviridae family of genus Lyssavirus, Rabies Virus (RABV). It is transmitted by the bite of a rabid animal and directly affects the CNS of the host (neurotropic). Sources of human rabies deaths are dogs (99%), cats, bats, etc. Rabies holds the seventh position in the world for causing the most severe infections that result in the death of an organism. India lies on the top in the number of affected individuals with rabies. Our aim in this study is to analyze the interactions between the RABV and its human host and to develop novel therapeutic strategies to combat this deadly disease. Further analysis of the predicted protein-protein interactions can help us design strategies against clinical manifestations of the disease in humans. An in-silico approach has been adopted because computational approaches play a vital role in providing an important tool in further investigation of host-pathogen systems.
K. Singla, K. Jatwani, A. Pandey, D. Malik, P. Chauhan, M. Rajbhar, A. Singh and K. Kumar *
Department of Biotechnology, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India.
02 February 2021
02 May 2021
29 May 2021
01 December 2021