MECHANISM OF ACTION OF A MULTI-HERBAL EXTRACT BLEND (KARALLIEF EASY CLIMB) IN SUPPORTING JOINT HEALTHAbstract
Osteoarthritis (OA) commonly affects many joints in the human body, including the knee joints. The knee joint is made up of two parts – the patella-femoral (PF) and tibiofemoral (TF) compartment. Animal models for OA studies are well-established and serve as an important tool for understanding the impact of OA in humans. This study evaluates the anti-OA potential of a multi-herbal extract blend product – KEC (KARALLIEF EASY CLIMB) against monosodium iodoacetate induced OA in wistar rats in-vivo. Animals have equally divided into four groups, of which one group was the control, and other three groups were experimental groups. Biomarker estimation and histopathological evaluation were carried out. All values were expressed as mean ± SEM. The significant difference between the treatment and control group was estimated using one-way ANOVA with Dennett’s test. All results of the statistical analysis were summarized in separate tables. In any case, the values were considered statistically significant at P<0.05. This study found that treatment with KEC reduced the Monosodium Iodoacetate (MIA) induced osteoarthritis condition. Anti-osteoarthritis activity of this product was confirmed through the measurement of various biomarker levels. Histopathological observations also confirmed that the treatment with KEC has inhibited/reversed the MIA-induced joint cartilage degeneration and subchondral bone alterations that lead to osteoarthritis.
K. Rajendran *, A. Godavarthi, K. Layton, R. Ramaswamy, R. Rajendran and K. Venkateshwarlu
Karallief Inc, Cambridge, MA, USA.
29 July 2021
07 September 2021
03 September 2021
01 May 2022