MEMBRANE SENSORS FOR THE SELECTIVE DETERMINATION OF TOLTERODINE TARTRATE IN PRESENCE OF ITS DEGRADATION PRODUCTAbstract
The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensors for determination of Tolterodine tartrate (TT) in presence of its oxidative degradation product are described. The sensors are based on the ion association complexes of TT cation with sodium tetraphenyl borate (TT-TPB) [sensor 1] or phosphomolybidic acid (TT-PMA) [sensor 2] counter anions as ion exchange sites in PVC matrix using dioctylphathalate (DOP) as plasticizer. The performance characteristics, sensitivity and selectivity of these electrodes in presence of TT oxidative degradation product were evaluated according to IUPAC recommendations. It reveals a fast, stable and linear response for TT over the concentration range 10-5-10-2 M with cationic slopes of 58.6 mV and 56.6 mV per concentration decade with sensors 1 and 2, respectively. The sensors are used for determination of TT, in pure form, in presence of its degradation product and in tablets. Validation of the method shows suitability of the proposed sensors for use in the quality control assessment of TT and for routine analysis as stability indicating method. The developed method was found to be simple, accurate and precise when compared with a reference method.
Khalid A. Attia, Nasr M. El-Abasawy, Ahmed M. Abdelraoof * and Mona H. Abdelrahman
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt
28 February, 2015
21 April, 2015
09 June, 2015
01 September, 2015