METAL COMPLEXES OF HETEROCYCLIC UNSATURATED 1, 3- DIKETONESAbstract
The present investigation is mainly on the synthesis, characterization and anti-microbial screening of certain new curcuminoid analogues containing imidazole, pyrrole and thiophene rings and their metal complexes. The ability of such heterocyclic β-dicarbonyl compounds and their metal ions to influence many of complex reaction upon which the vital processes of micro-organisms depends is the motivation behind the work. A series of 5- hetero aryl-1-phenyl-4-pentene-1,3-diones(1a-c) and their Cu (II), Ni (II) complexes of ML2 stoichiometry were synthesized and characterized by UV, IR, mass and 1H NMR spectroscopies. Analytical and spectral data suggest neutral bidentate coordination for unsaturated diketone with metals. Anti-microbial screening was carried out by using Kirby-Bauer disc plate method. All the ligands and their metal complexes showed significant anti-microbial action. Further complexation; seem to augment the antimicrobial activity of the compounds.
K.L. Krishnakumar* and Mathew Paul
Assistant Professor, Department of Chemistry, Nehru College of Pharmacy, Thrissur, Kerala, India
25 November, 2012
21 January, 2013
23 February, 2013
01 March, 2013