METAL COMPLEXES OF RIBAVIRIN; SYNTHESIS, CHARACTERIZATION AND IN-VITRO BIOLOGICAL SCREENINGAbstract
Medicinal applications of metals and its compound were reported centuries ago but it gained huge appreciation after the discovery of anticancer activity of metal based drug cisplatin. After cisplatin discovery many medicinal synthetic chemist moved into the field of organometallics for combating diseases and investigating the excellent pharmaceutical potential of metal complexes, giving birth to modern medicinal organometallic chemistry. Derivatization of the already existing drugs is the emerging field of pharmaceutical and synthetic medicinal chemistry. Working on metal complexes of already approved drugs can substantially reduce the time and money spent in clinical development. Organotin(IV), Cu(II), Zn(II), Fe(III) and Sb(III) complexes of Ribavirin were synthesized keeping the same in mind. These complexes were characterized by elemental analysis, IR, 1H, and 13C NMR spectroscopic studies. The synthesized complexes and the parent drug were screened for in-vitro biological activities. Interestingly some of the synthesized metal complexes of ribavirin have shown impressive antibacterial and antifungal on the other hand ribavirin was found to be inactive.
S. Akhtar *, M. A. Khan, K. Shahid and H. Akhtar
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
12 June, 2017
13 March, 2018
18 March, 2018
01 April, 2018