MICRO-COULOMETRIC ESTIMATION OF NITROFURANTOINAbstract
The objective of the present work was to set up micro-coulometric technique in the laboratory and estimate microgram level quantity of nitrofurantoin in the pharmaceutical tablets. A simple, sensitive, and reproducible manually operated microcoulometric technique has been successfully used for the estimation of nitrofurantoin in pharmaceutical tablets. A potentostat and coulometric cell was used in the technique. A coulometric cell was consist of mercury pool electrode, spiral silver electrode, and saturated calomel electrode. The accuracy of the current was 1µA and applied potential was 0.001 volt against SCE. Further, the prepared tablet solution of nitrofurantoinin ammonia buffer of pH 9.0 was estimated and statistical analysis of the data were carried out. Polarogram of the nitrofurantoin in ammonia buffer of pH 9.0, shows that six electrons are involved in the reduction of nitrofurantoin. The lowest limit of estimation of nitrofurantoin was 15ug. The reprodusability of estimation i.e. relative root mean square error(RMSE) was less than 2µg. The recovery was 100 ± 5%.
Sushil B. Kapoor *, Parmanand M. Shende and Dilip B. Patil
Arts, Commerce and Science College, Tukum, Chandrapur, Maharashtra, India
30 July, 2016
19 September, 2016
26 September, 2016
01 February, 2017