MICROBIAL L-ASPARAGINASE: A REVIEW ON CURRENT SCENARIO AND FUTURE PROSPECTSAbstract
L-Asparaginase (E.C. 188.8.131.52.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma. This article has briefly touched nearly all the industrial and clinical aspects of L-Asparaginase and provides the recent update of the topic. The article includes a brief introduction to the topics, mechanism of action, a little information about the structure, sources of enzyme, purification, optimum conditions for the enzyme production, recombinant strains for higher productivity and formulation of the enzyme.
S. Kumar Jha*, Divya Pasrija, Rati Kumari Sinha, Hare Ram Singh, Vinod Kumar Nigam and Ambrish Sharan Vidyarthi
Department of Biotechnology, BIT Mesra, Ranchi, Jharkhand, India
05 May, 2012
12 July, 2012
16 August, 2012
01 September, 2012