MICROENCAPSULATION OF ISONIAZID BY TEMPERATURE CHANGE METHOD: PREPARATION AND CHARACTERIZATIONAbstract
|Aim: Isniazid is unstable in aqueous medium. The aim is to improve the aqueous stability of isoniazid by microencapsulation method. Methods: Isoniazid microcapsules were prepared by temperature change method. Ethyl cellulose used as coating material which forms a layer on pure drug. Ethyl cellulose was insoluble in cold cyclohexane when temperature rise about 70-750C it become soluble in cyclohexane.
Result: Isoniazid was reported unstable in aqueous medium and their high acetylation occurs in liver. Microcapsules were prepared by temperature change method. The average particle size of isoniazid microcapsules was found to be 57µm and angle of repose was 23.560, flow rate 0.85gm/sec. Isoniazid in pure form released 90% about in 50 minutes. After microencapsulation T90% was increased from 50 minutes to about 4 hours.
Conclusion: After microencapsulation improved the physical properties like bulk density, particle size, and flow characteristics. Isoniazid microcapsules also show prolonged the release by following first order kinetics and enhanced the stability in aqueous medium.
Athar Husain*, Amit Kaushik and Mohd. Rashid Ansari
Mahatma Gandhi Institute of Pharmacy, Junabganj, Kanpur Road, Banthra, Lucknow, U.P. India-227101
28 January, 2014
01 March, 2014
08 April, 2014
01 July, 2014