MICROSPHERES: A NOVEL APPROACH FOR DELIVERY OF ANTIHYPERLIPIDEMIC DRUGSAbstract
Microsphere drug delivery is a novel drug delivery approach for sustaining and controlling the rate and release of active pharmaceutical ingredients. Microspheres are the choice of drug delivery for delivering the drug at a specific site to release the encapsulated drug to treat various diseases. Microspheres drug delivery is an attractive dosage form in terms of its flexibility and sustaining the release as compared to other sustained and controlled formulations. Most of the antihyperlipidemic drugs come under BCS class-II, which leads to poor solubility but higher permeability, the oral bioavailability of statins categories drug possess less bioavailability due to the poor solubility; hence microspheres are the best candidate for delivering antihyperlipidemic drugs to the systemic circulation and improving the systemic bioavailability of drug for a longer period with lesser adverse effects. Therefore microspheres can be used in various medical departments like oncology, gynecology, radiology, pulmonary, cardiology, diabetes, vaccine therapy, etc. this review article focuses on recent different methods of preparation. The microspheres formulated can be later evaluated and characterized by a different procedure.
Akbal Ahmad * and Abadhesh Kumar Niranjan
Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh, India.
05 August 2021
26 October 2021
17 November 2021
01 June 2022