MICROSPHERES AS DRUG CARRIERS FOR CONTROLLED DRUG DELIVERY: A REVIEWAbstract
Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. Microspheres have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, to simulate controlled drug release. Microspheres are characteristically free flowing solid powders, which consist of proteins or synthetic polymer, which are biodegradable in nature. Microspheres having particle size in range between 0.1-200 µm, can be delivered by several routes like oral, parentral, nasal, ophthalmic, transdermal, colonal etc. Various recent advancement in case of microspheres like mucoadhesive, hollow, floating, microballons, magnetic have been contributed to overcome the various problems that are associated with the use of microspheres, which includes site specific targeting and improved release kinetics. In future by combining various new strategies, microspheres will find a central place in novel drug delivery, particularly in diseased cell sorting, genetic materials, safe, targeting and effective drug delivery.
Nisha Sharma *, Neha Purwar and Prakash Chandra Gupta
University Institute of Pharmacy, C.S.J.M. University, Kanpur , Uttar Pradesh, India
05 May, 2015
22 June, 2015
30 August, 2015
01 November, 2015