MICROSPONGES: A PROMISING APPROACH FOR DRUG DELIVERYAbstract
Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres. The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and crannies of skin. Thus slowly release the drug for a prolonged period. It prevents the excess accumulation of drugs within the epidermis and dermis. They have a modified drug release pattern with lesser side effects. Micro sponges are biologically safe and provide a selective advantage of programmable drug release. Micro sponges Drug Delivery System provides entrapment of ingredients because of its porous nature and is believed to contribute lesser side effects, improve drug stability, increase elegance, and enhance formulation flexibility. One of the best features of microsponges is their self- sterilizing property. Several studies have confirmed that Micro sponges are non-mutagenic, non-allergic, non-irritant, and non-toxic. This review focused on preparation, characterization, release mechanism, and other Micro sponges Drug Delivery System parameters.
Ranu Biswas *, Sayani Saha, Chayanika Chatterjee and Samrat Ghosh
BCDA College of Pharmacy & Technology, Jessore Road, Hridaypur, Barasat, Kolkata, West Bengal, India.
19 January 2021
26 June 2021
15 July 2021
01 January 2022