MICROWAVE-ASSISTED SYNTHESIS AND IN-SILICO SCREENING OF NOVEL SUBSTITUTED 1, 3, 4-THIADIAZOLE DERIVATIVES FOR TREATING ANTIVIRAL AGENTS
AbstractBackground: Cancer is one of the deadly diseases, accounting for nearly 10 million deaths every year. Cancer is one of the leading dreadful conditions which most people. Cancer is may due to genetic change, which interferes with normal growth mechanisms. A mutant cell divides and produces abnormal masses. Cancer cells can break away from the mass (or tumour) and travel via the bloodstream or lymphatic system to different body parts. These cells can settle in other body parts to form secondary cancer or metastasis. Various approaches have been introduced to eradicate cancer. Objective: In this literature, we aim to study the In-silico molecular docking for Thiadiazole derivative with an anti-tumor receptor. Methodology: We have used Argus lab software for molecular docking. Ligand is prepared using Chemsketch software and proteins are prepared using Chimera software. Main Observation: our study shows that the binding value lies between -9.7 to -7, and hydrogen bonds are formed. Conclusion: Our study concludes that the Thiadiazole derivative forms good binding affinity with chosen receptors and suggests it can be further developed in future studies.
Article Information
11
3916-3921
4342 KB
460
English
IJPSR
S. Gejalakshmi * N. Harikrishnan, S. Rajesh, S. Pooja, A. Divyasri and G. E. Thillai Govindarajan
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Dr. M. G. R. Educational and Research Institute Velappanchavadi Chennai , Tamil Nadu, India.
gejampharm@gmail.com
12 February 2022
04 May 2022
20 September 2022
10.13040/IJPSR.0975-8232.13(10).3916-21
01 October 2022
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