MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA-CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATSAbstract
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are the main stay of AD therapy. In the present study, the effect of Minocycline, a tetracycline derivative, was investigated against intracerebroventricular streptozotocin induced cholinergic deficits. Intracerebroventricular administration of streptozotocin (3mg/kg) bilaterally on day 1 and 3 was able to produce significant cholinergic deficits as evidenced by increase in level of acetylcholinestrase while chronic treatment with Minocycline (10, 20 and 40mg/kg, i. p.) for 21 days significantly decreased it. The results of the present study support the candidature of Minocycline in learning and memory disorders resembling dementia of Alzheimer’s type.
Vivek Kumar Sharma*, Ashok Goyal and Subrahmanya G Sarma
Department of Pharmacology, Govt. College of Pharmacy, Rohru, Shimla (HP), India
10 May, 2010
08 July, 2010
09 August, 2010
01 September, 2010