MIR AND NIR SPECTROSCOPY AS RAPID METHOD TO QUANTIFY MOLSIDOMIN IN GENERIC TABLETAbstract
This work investigates the potential of Partial Least Square (PLS) regression using two vibrational spectroscopies as mid infrared (MIR) and near infrared (NIR) spectroscopies for the quantification of molsidomin in tablets. Two very simple, rapid, inexpensive and green strategies were applied for this determination. Powder blends containing molsidomin and excipients were prepared. The excipients correspond to those in Inverter® tablets. Two experimental design approaches were used in generating 9-levels % calibration and validation samples sets. Fourier transforms of mid-infrared (MIR) and near-infrared (NIR) spectra were measured by transmission and diffuse reflection techniques respectively. The calibration models were generated by PLS models without spectral treatment and were used to predict the drug content in the powder blends made for validation models and for commercial tablets. The mean percentages of recoveries for the analysis of molsidomin in generic Inverter® 4 mg tablet are 101.5 and 99.6 % for FT-MIR and FT-NIR respectively.
C. Boyer , A. Boudis , Jp. Dubost* and K. Gaudin
Pharmaceutical and Analytical developments applied to neglected diseases and Counterfeits , EA 4575, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux CEDEX, France
11 January, 2014
27 March, 2014
26 April, 2014
01 July, 2014