MITIGATING POTENTIAL OF ALLLIUM SATIVUM ON ARTESUNATE INDUCED RENAL TOXICITY IN MALE MICEAbstract
In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antimalarial drug, artesunate, which has been used as an alternative antimalarial drug against conventional drugs like chloroquine. Thirty six male mice were divided into six experimental groups. In the present study, Allium sativum was given at 100 mg/kg body weight with low dose (150 mg/kg body weight) and high dose (300 mg/kg body weight) of artesunate for 14 days and 21 days duration. Obtained results showed significant alterations in gravimetric indices as well as biochemical parameters. Moreover, administration of Allium sativum exhibited recovery and reestablishment of various altered indices in renal tissue as opposed to artesunate treated groups. This study obviously demonstrated that treatment with Allium sativum significantly attenuated the renal toxicity induced by artesunate in Mus musculus. Thus, it can be concluded from the observed results that Allium sativum could be used as a potent mitigating agent against antimalarial drug toxicity.
K. R. Desai, D. K. Rajput, P. B. Patel, J. P. Pandit and H. N. Highland
Department of Zoology, BMT and HG, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, Gujarat, India.
08 September, 2016
22 October, 2016
17 November, 2016
01 March, 2017