MITOGENIC, ANTIOXIDATIVE AND ANTIMICROBIAL ACTIVITIES OF G-90 AND COELOMIC FLUID FROM EARTHWORM AS A THERAPEUTIC AGENT, A REVIEWAbstract
The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part. These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid. The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication. The antimicrobial activity prevents the wounded area from bacterial infection and enhances cell division. This review aims to promote cheap natural products of earthworms to be used widely in human medicine. Thus, we reviewed how to extract coelomic fluid, preparation of tissue homogenate (G-90) and application of mitogenic, antioxidative, antimicrobial activities on experimental animal rats, mice and rabbits. These products were efficient for hasty wound healing, the proliferation of damaged bone, boosting of immune cells and nerve cell regeneration without carcinogenic and mutagenic characteristics. Therefore, the biotechnological application of tissue homogenates and coelomic fluid should get due attention.
K. Gudeta *, S. Kumari, A. Bhagat, J. M. Julka and R. Goyal
Faculty of Biological and Environmental Sciences, Shoolini University Biotechnology and Management Sciences, Solan, Himachal Pradesh, India.
13 January 2020
23 March 2020
16 October 2020
01 November 2020