MIXED HYDROTROPY TECHNIQUE USED FOR SOLUBILITY ENHANCEMENT OF ALBENDAZOLEAbstract
Purpose: Albendazole (ABZ) is a drug that shows anthelmintic activities, also used for treating neurocysticercosis, also known as pork tapeworm infection caused by contact with infected human stool, infected food, and water. But the serious challenge is the hydrophobicity of albendazole, which slow down the dissolution rate and bioavailability, so it can be given in high concentration, which can cause residual toxicity, so the purpose of this research article is to enhance the solubility of albendazole by mixed hydrotropic technique. Hydrophobic drug shows the difficulty in absorption when reaching the aqueous area, leading to failure in formulation development. Method: Solid dispersion was prepared by using a blend of citric acid and piperazine by mixing them with ABZ with the help of ethanol as solvent, carried out the content in a china dish on a magnetic stirrer until solvent evaporated completely, use of FTIR for functional group determination, determination of melting point by capillary method, determination of thermal behaviour by DSC, XRD studies were done, Further evaluation of solid dispersion were done for determination of drug content, Percentage yield, solubility studies, and In-vitro evaluation. Results: In the present observation, an attempt was made to enhance the solubility of hydrophobic drug albendazole by using a blend of hydrotropes such as Citric acid and piperazine as hydrotropes and ethanol as a solvent which enhanced the solubility of ABZ up to 5 times. Conclusion: Based on research work, it was concluded that mixed hydrotropy enhanced the solubility of ABZ by using piperazine and citric acid as hydrotropes which also reduces the chances of residual toxicity.
Akanksha Hatwal *, Rita Saini and Shivanand Patil
Department of Pharmacy, Shree Dev Bhoomi Institute of Education Science & Technology, Dehradun, Uttarakhand, India.
12 June 2022
21 July 2022
04 August 2022
01 February 2023