MOLECULAR DOCKING STUDIES OF THE COMPOUNDS FROM PERGULARIA DAEMIA AND TERMINALIA CATAPPA L. LEAF EXTRACTS WITH CYP2E1,GST,UDP-GLUCURONYL TRANSFERASE AND Nrf2 BINDING SITE IN KEAP1, IL-6Abstract
Objective: Pergularia daemia and Terminalia catappa L.. Leaf extracted with hydroethanol and the extracts were separated by silica gel column chromatography. The selected column fractions are used in GC-MS analysis, from the GC-MS results eight phytochemical compounds are selected based on their biological activities. In the present work we predict the interaction of the selected targeted proteins (CYP2E1, UDP-GT, GST and Nrf2 binding site in keap1 protein,IL-6) with bioactive compounds of the extracts (HAEPD and HAETC) by molecular docking studies. The number of bioactive compounds present in HAEPD and HAETC, and there phytochemicals are responsible for various biological as well as hepatoprotective and anti hepatotoxic properties of the plant extracts.
V. Packirisamy and K. Vijayalakshmi *
Department of Biochemistry, Bharathi Women’s College, Chennai, Tamil Nadu, India.
28 July, 2017
13 October, 2017
24 April, 2018
01 May, 2018