MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM – A COMPREHENSIVE AND PROMISING NOVEL DRUG DELIVERYAbstract
Since Dr. Tsuneji Nagai of Hoshi University, Japanin the early 1980’s used the concept of bio adhesion for the delivery of insulin across the buccal mucosa in beagle dogs; several researchers tried a large number of drugs for administration through buccal mucoadhesive dosage forms. The potential of these dosage forms have been found to be tremendous because of their ability to improve the bioavailability of many such drugs by bypassing the hepatic first pass metabolism. Because of the growing number of newer molecules in the form of peptides and proteins, the research in this field has gained the centre stage for the non-invasive drug delivery as an alternative to parenteral route. The novel design of the buccal delivery system can be achieved by the help of polymers of synthetic and natural polymers. The purpose of this review article is to establish the developments and highlight the importance of mucoadhesive buccal delivery for low bio available drugs.
Nallathambi Ramasamy* and V. Gopal
Prist University, Vallam, Tanjore-613403, Tamil Nadu, India
13 November, 2013
26 January, 2014
09 March, 2014