MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM: A REVIEWAbstract
As an alternative to injection pharmaceutical researcher and scientist are trying to explore transdermal and transmucosal route over the last few years. To overcome the deficiency associated with the other route of administration buccal region of oral cavity is an alternative target for the administration of choice of drug. The disadvantages relative with the oral drug delivery is the extensive presystemic metabolism, instability in acidic medium as a result inadequate absorption of the drugs. However parental route may overcome the drawback related with the oral route but these formulations have high cost, supervision is required and least patient compliance. By the buccal route the drug are directly pass through into systemic circulation, less hepatic metabolism and high bioavailability. The aim of the review article is an overview of buccal drug delivery, anatomy of oral mucosa, mechanism of drug penetration and their in-vitro and in-vivo mucoadhesion testing method.
Jasvir Singh* and Pawan Deep
School of Pharmaceutical Sciences, Shoolini University, Solan- 173 212, Himachal Pradesh, India
08 November, 2012
21 December, 2012
21 February, 2013
01 March, 2013