MULTIUNIT FLOATING DRUG DELIVERY SYSTEM A SIGNIFICANT TOOL FOR THE TREATMENT OF PEPTIC ULCER DISEASEAbstract
The gastroretentive drug delivery system has been utilized to obtain prolonged and uniform release of drug in stomach. Thus increase bioavailability and decrease the administration frequency. A peptic ulcer is a break in the lining of the stomach, esophagus or duodenum. Peptic ulcer may be due to H. Pylori bacteria, acid of the stomach cell or nonsteroidal anti-inflammatory drugs (NSAIDS). The gastroretentive drug delivery system may be single unit (floating tablet) or multiunit system (floating microspheres). The single unit floating system is more popular but has the disadvantage that its purpose would not be achieved if it fails to float or rapidly emptied from stomach. The multiunit floating system may be better because they reduce inter subject variability in absorption and also lower the probability of dose dumping. Thus, the purpose of preparing multiunit dosage form is to be developing suitable formulation and has all the advantage of a single unit dosage form and also devoid of disadvantage of single unit formulation
P. Singh , V. K. Chaudhari *, P. K. Verma , A. K. Singh and V. K. Yadav
Department of Pharmacy , Kunwar Haribansh Singh College of Pharmacy, Jaunpur, UP, India.
21 July, 2014
30 October, 2014
12 December, 2014
01 April, 2015