NANO – STRUCTURED HERBAL ANTIMICROBIALSAbstract
The use of traditional medicines of natural origin is being encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may cause unpredictable adverse effects. The various strategies which have been identified to defeat drug resistance, the investigation of new and effective natural products exhibiting antimicrobial activity against pathogenic microorganisms is likely to play a significant role to overcome drug resistance. The numbers of global infections produced by bacterial strains that are resistant to single and multiple antimicrobial drugs are on the rise. With emerging trends in nanotechnology it has become possible to address the problems associated with potential natural products to be developed as antimicrobial drug. Nanomaterials can improve the pharmacokinetics, bioavailability, therapeutic index and specificity of plant origin drugs. By smartly designing nanoscale carriers, therapeutic value of natural products can be drastically improved, number of plant origin drugs can enter into clinical trials and antimicrobial resistance can be cured. Nanosizing led to increase solubility of components, reduction in the dose via improved absorption of active ingredient. Thus, nanonization improve the problem of antimicrobial resistance.
Rachna Gupta*, Pramod W. Ramteke , Himanshu Pandey and Avinash C. Pandey
Department of Biological Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad- 211007, Uttar Pradesh, India
15 February, 2013
18 May, 2013
27 May, 2013
01 June, 2013