NANO STRUCTURED LIPID CARRIER SYSTEM- A NOVEL TARGETING CARRIERAbstract
Oral administration of drugs is considered a convenient route; however, various drugs that are insoluble in water or cannot permeate across gastrointestinal tract membrane cannot be delivered by this route. To enhance the permeability through the physiological barriers, lipophilic drugs are introduced but, lipophilic drugs have low oral bioavailability. To enhance the bioavailability, a third-generation lipid matrix was introduced as nanostructured lipid carriers (NLCs), which are a mixture of solid lipids mixed with some incompatible liquid-lipids. NLCs have been reported to be an alternative system to emulsions, liposomes, microparticles, solid-lipid nanoparticles (SLNs). This article mainly focuses on the types and methods of preparation, advantages, the applicability of NLCs in the present and in the near future.
S. Satya Lakshmi and K. Persis Joni *
Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh, India.
20 October 2020
07 May 2021
27 May 2021
01 December 2021