NANOEMULSION: A SNAPSHOT ON DEVELOPMENT, CHARACTERIZATION, APPLICATIONS, PATENTS AND CLINICAL TRIALSAbstract
Nanoemulsionis a special case of emulsion. It is nano-sized emulsion used as a carrier. It has the ability to deliver the drug to the target site. It is a good vehicle for the controlled delivery of the drug. It is prepared by the high energy and low energy emulsification method. Emulsifier plays an important role in stabilizing the nanoemulsion. It is anisotropic and thermo-dynamically stable system of oil, water and surfactant-co-surfactant (Smix) in an appropriate proportion. Nano-emulsion has a droplet size in between 20-200 nm. NE has the ability to encapsulate both the lipophilic and hydrophilic drug in o/w and w/o systems, respectively. Hence, improved solubility, as well as enhanced bio-availability of the drug, can be achieved through nanoemulsion. For stabilizing o/w and w/o type NE, both hydrophilic and lipophilic surfactants are used at once. The present review article is highlighted on various aspects of formulation-development, patents, and clinical trials of NE and its wider application to the different area.
R. Deshmukh, B. Sharma, R. K. Harwansh and B. Dewangan *
Shri Shankaracharya Institute of Medical Sciences, Bhilai, Chhattisgarh, India.
07 April 2020
24 August 2020
12 September 2020
01 April 2021