NANOGELS: AN OVERVIEW OF PROPERTIES, CLASSIFICATIONS, DRUG TARGETING METHODS, EVALUATION PARAMETERS AND APPLICATIONS

Nanogels (NGs) are advanced and innovative drug delivery systems that play an important role in remarking many issues that are associated with recent and trendy courses of treatment, such as non-specific effects and low stability. NGs could be well-defined as extremely cross-linked hydrogels (nano-sized) ranging from 20-200 nm. NGs are vigorous nanoparticles (NPs) used to deliver active drug complexes for the controlled delivery of drugs. This system is simpler and safer for both hydrophobic and hydrophilic drugs because of their chemical composition and formulations that are unsuitable for different formulations. Drugs are incorporated into NGs for many purposes, like gene targeting, organ targeting, diagnosis, and many more. NGs can be administered through different pulmonary, nasal, transdermal, intra-ocular, oral, and parenteral routes. Frequently, NGs are used to treat cancer, bone regeneration, inflammation, etc. This NGs system is a novel drug delivery system for hydrophobic and hydrophilic drugs. This review mainly focuses on providing general information on NGs, their properties, various classifications, drug targeting methodology, different types of drug delivery systems, evaluation methods and novel applications of NGs in detail.