NANOPHYTOSOMES AN IMPERATIVE TECHNOLOGY FOR ENHANCING THE BIOAVAILABILITY OF BIOACTIVE CONSTITUENTSAbstract
Herbal medicine has been widely accepted as a promising approach for the treatment of various diseases with lower cost and minimized toxicity. Bioactive constituents isolated from the herbal source are equipped with synthetic drugs. The potency of any herbal medication is contingent on the delivery of the effectual level of the therapeutically active constituent. The integration of a novel drug delivery system in a traditional system of medicine enriches the potentiality of herbal drugs. Several plant extracts and phytoconstituents, despite having excellent bio-activity in-vitro demonstrate less or no in-vivo actions due to their poor lipid solubility or improper molecular size or both, resulting in poor absorption and poor bioavailability. Nan technological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus, obtain a greater bioavailability. Phytosome technology is one such novel approach that enabled in making phytoconstituents more bioavailable. In this review, a comprehensive discussion with respect to the methods and characterization of nanophytosomes of herbal preparations is presented.
D. Lavanya * and A. S. Devi
Department of Pharmaceutical Chemistry Seven Hills College of Pharmacy Tirupati, Andhra Pradesh, India.
22 August 2019
12 October 2019
29 February 2020
01 June 2020