NANOSUSPENSION: A PROMISING DRUG DELIVERY SYSTEM FOR POORLY WATER SOLUBLE DRUG AND ENHANCED BIOAVAILABILITYAbstract
Nanosuspension consists of a submicron colloidal dispersion of pharmaceutically active ingredient particles in the liquid phase, which is stabilized by surfactant. Poor water solubility is a major problem for the manufacturing of formulation. The drug particle reduces leads to enhance the surface area as well as bioavailability. Nanosuspension prepared by way of a number of methods. Techniques such as media milling, high-pressure homogenization have been used commercially for producing Nano-suspension. Recently engineering of nanosuspension employs emulsion and microemulsion as a templet. The unique feature of Nanosuspension has enabled its use in different dosage forms and delivered by using various routes such as an oral, pulmonary, ocular, topical, and mucoadhesive hydrogel. The benefits of nanosuspensions are improved drug dispersibility and drug solubilization, improved therapeutic efficacy and reduced toxicity. Therefore, the present review described the achievements of nano-suspensions in the drug delivery system in order to enhance the solubility, stability, and bioavailability of the drugs. This review article describes the preparation methods, characterization, and applications of the nanosuspensions.
M. S. Hussain *, A. B. Ahmed and J. Debnath
Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Hattkhowapara, Azara, Guwahati, Assam, India.
23 December 2019
10 September 2020
18 September 2020
01 October 2020