NANOSUSPENSION – A PROMISING TECHNIQUE FOR POORLY SOLUBLE DRUGSAbstract
Most pharmaceutical drugs create problems during formulation as they are insoluble or poorly soluble in aqueous and non-aqueous mediums. It was proved that reducing the drug particle size increases the drug’s Solubility, Dissolution and Bioavailability. Many conventional techniques may be used, but the desired amount of particle size may not be achieved, and Solubility, Dissolution and Bioavailability still be a problem. Nanotechnology is a promising technique for formulating poorly soluble drugs. Nanotechnology helps us to reduce the drug particle size to submicron level and due to this, drug particle surface area increases which lead to solubilization of the drug. An increase in solubility leads to increased dissolution and Bioavailability of drug which leads to an increase in the drug’s effectiveness. Also, Nanotechnology has many advantages over conventional techniques. One of the most important advantages of Nanotechnology is that particle size can be reduced from 300 nm to 10µ. Nanotechnology helps us formulate insoluble drugs in aqueous and non-aqueous mediums into different dosage forms without using harsh organic solvents for solubilizing purposes, which reduces the risk of toxicity. This review describes how to formulate a drug into Nanosuspension and gives detailed information about the Advantages and Disadvantages of Nanosuspensions, Ingredients used in Nanosuspension, Methods of preparation, Characterization of Nanosuspension, and Application of Nanosuspension in Pharmaceutical Dosage Form.
H. M. Shinde *, P. H. Khade and A. V. Bhosale
Department of Pharmaceutics, PDEAs Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India.
26 July 2022
10 October 2022
06 November 2022
01 May 2023