NATURAL ACID CATALYSED SYNTHESIS OF SCHIFF’S BASES FROM 1-(1-PHENYL-ETHYLIDENE) SEMICARBAZIDE

The natural acid like lemon juice provides mild acidic state which used to catalyzed reaction of primary amine and aldehyde in green solvent like ethanol at room temperature reflux for 1.5 hour gives Schiff bases in good yield. Schiff bases have attracted considerable attention of us due to their significant biological activities ¹ like anticancer, antitumor, anti inflammatory agents ⁴, insecticidal, antibacterial ⁵, antituberculosis, antimicrobial ^2-3, antifungal ⁵, anti-HIV and metal corrosion inhibition activities of Schiff bases, besides wide range of pharmacological activities. Natural acid is non-polluting and does not employ any lethal materials, quantifying if as a green approach for the synthesis of Schiff bases. Schiff bases also have several types of biological actions such as analgesic and antimalerial ⁶. They are working as Ligands for complexes of metal ions. Organosilicon complexes with Schiff bases are found to be beneficial in various agricultural applications like fungicides, bactericides, herbicides, acaricides and antifeedants ⁷. The metal complex of Schiff bases are also of principal significance in analytical chemistry and chemotherapy ⁸.