NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF STEM BARKS OF CRATAEVA NURVULA BUCH HUMAbstract
Aim of the study: Now a days due to the hammering of movies and fashion most of the people specifically age group between 18 to 30 years, are diverted more to have the protein supplements in excess for getting good physique and well toned body shape. The people suppose to eat more calcium, vitamins and some steroids with intension that they will get done the things too fast. Without been having good trainee and medical supervisor most of the people doing exercise in the fitness club and gym and taking the diet which is one of the major cause of nephrotoxicity. Materials and Methods: Ethanolic extract of stem barks of Crataeva nurvula Buch hum in the doses of 200 mg, 400 mg and 600 mg is useful as a laxative, demulcent, stomachic, and is reported to cure disorders of urinary organs. It is also very useful as anti-inflammatory drug and act as a good contraceptive for women and also used in arthritis. Results: In the current study, effects of pretreatments with the stem barks of ethanolic extract of Crataeva nurvula Buch hum were investigated in Cisplatin induced nephrotoxic rats for 24 hours using renal function parameters such as serum urea (UR), uric acid (UA) and creatinine (CR). Effects of the extract pretreatments on the hematological profile in Cisplatin nephrotoxic rats were evaluated. The extract also significantly (p<0.05, p<0.01, p<0.001) improved packed cell volume (PCV), hemoglobin (Hb), and total leukocyte count (TLC) levels but non-significant (p>0.05) increase in the mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). Conclusions: The overall result suggests that the stem bark extract of Crataeva nurvula Buch hum possesses nephroprotective potential and improves hematological derangements associated with Cisplatin nephrotoxicity. Although, the active principles were not isolated and their possible mechanisms of actions were not investigated in the present study, these could constitute areas of future studies.
T. T. Shelkea*, V. H. Bhaskarb, P. P. Adkara, U. Jhaa and R. J. Oswala
HOD, Department of Pharmacology & Toxicology, JSPM’S Charak College of Pharmacy & Research, 720/1&2 Wagholi, Nagar road, Maharashtra, Pune- 412 207, India
22 June, 2011
03 August, 2011
18 September, 2011
01 October, 2011