NEUROBIOLOGICAL EVALUATION OF DERIVATIVES OF SUBSTITUTED PHENYL-ETHYLAMINE AND ETHYLAMINEAbstract
Cognitive functions are mainly categorized into memory, attention, creativity, and intelligence. Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind. Phenylethylamine is an organic compound which is also known as β-phenylethylamine (β-PEA) and is the name of a class of chemicals which shows psychoactive and stimulant effects. It is a trace amine and a natural monoamine alkaloid. PEA plays an important role in weight loss, treating depression, ADHD and Alzheimer’s disease, etc. The main objective of this study is to synthesize derivatives of ethylamine and phenyl-ethylamine, which may inhibit MAO receptors and improve cognitive behavior. All synthesized derivatives were studied for their biological evaluation on the brain, and they showed the good neurological activity and found effective to reverse the memory deficits induced by scopolamine. While, there is no significant effect was seen in the locomotor effect, which represent that these agents are effective to control the motor coordination.