NEUROPROTECTIVE AND ANTIOXIDANT ROLE OF PREGABALIN IN STREPTOZOTOCIN INDUCED NEUROTOXICITYAbstract
Streptozotocin (STZ) induced neurotoxicity causes development of diabetic neuropathy in rodent models and oxidative stress is the main culprit in development of diabetic neuropathy. In the present study we aimed to evaluate the neuroprotective and antioxidant role of Pregabalin in STZ induced neurotoxicity. After 8 weeks, STZ induced diabetic rats showed sciatic nerve damage which was evident from hyperalgesia, allodynia, motor deficits and Transmission Electron Microscopic studies of sciatic nerves. Pregabalin treatment at a daily dose of 15 mg/kg for 7 weeks ameliorated hyperalgesia, allodynia, motor deficits and prevented the structural abnormalities in sciatic nerves of diabetic rats. STZ neurotoxicity reduced antioxidant enzyme levels in sciatic nerves. Pregabalin treatment significantly ameliorated the decrease in antioxidant defence in diabetic rats. These results demonstrated neuroprotective effect of Pregabalin, which is mediated through attenuation of oxidative stress. The antioxidant mediated neuroprotective role along with its analgesic activity can prove it as a better option in prevention and treatment of Diabetic neuropathy.
Archana Jorige * and Akula Annapurna
RBVRR Women’s College of Pharmacy (Affiliated to Osmania University), Barktpura, Hyderabad, Telangana, India.
27 May, 2016
12 July, 2016
27 July, 2016
01 November, 2016