NEUROPROTECTIVE EFFECT OF MADHUCA LONGIFOLIA LEAF EXTRACT AGAINST COLCHICINE: AN EXPERIMENTAL STUDY ON COGNITIVE DYSFUNCTION AND BIOCHEMICAL ALTERATIONS IN MICEAbstract
The goal of the research was to explain as a cognition enhancer the traditional claim of Madhuca longifolia (Sapotaceae) leaves. Dementia was activated by intracerebrovascular colchicine administration for 28 days. Madhuca longifolia leaves ethanolic extract was evaluated in mice for cognition-enhancing activity in colchicine-induced dementia using elevated plus maze (EPM), actophotometer, and biochemical estimation of brain AChE and MDA levels. Piracetam (200 mg/kg p.o.) was used as standard medicine. Transfer latency (TL) was observed in the colchicine-induced mice using EPM, showing a significant increase (p<0.01) in TL compared to the regular control group. No major effect was found on the locomotor activity of the mice. In colchicine-induced mice, a significant increase (p<0.01) in AChE and a decrease in MDA levels relative to normal control were observed. These results formed the standard argument, and Madhuca longifolia can therefore be a memory enhancer because of the presence of flavonoids.
Pragati Khare *, Kamal Kishore and Dinesh Kumar Sharma
Department of Pharmacy, Shri Ram Murti Smarak, C.E.T., Bareilly, Uttar Pradesh, India.
27 January 2021
09 May 2021
29 May 2021
01 December 2021