NEW SPECTROPHOTOMETRIC DETERMINATION OF KETOROLAC TROMETHAMINE BULK AND PHARMACEUTICAL DOSAGE FORM
AbstractA new, selective and sensitive visible spectrophotometric method has been developed for the estimation of Ketorolac tromethamine in bulk and pharmaceutical preparations. The method is based on the reaction of ketorolac tromethamine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone (DDQ) to form red color charge–transfer complex with a λmax. 460nm extracted in methanol. Beer’s law is obeyed in the concentration range of 50 to 250µg/ml for the method. The method is extended to pharmaceutical formulations and there was no interference from any common pharmaceutical excipients and diluents. The result of analysis has been validated statistically and by recovery studies
Article Information
40
4848-4850
495
1491
English
Ijpsr
A.J. Pratapareddy and I.E. Chakravarthi
Department of Chemistry, K.V.R.P.G College, Nandigama, Andhra Pradesh, India
jpreddy14160@gmail.com
13 August, 2012
26 September, 2012
24 November, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(12).4848-50
01 December, 2012
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