NEWER ADVANCEMENT IN NASAL DRUG DELIVERY SYSTEMAbstract
Over the past two decades, intranasal drug delivery has shown tremendous promise for systemic delivery of therapeutic agents, although the potential of the nose as a route of administration has been known since ancient time. Psychotropic and hallucinogenic agents have been used as snuff in many parts of the world for hundreds of years. Because of rich vasculature and highly permeable structure, nasal route could be used as an alternative to parenteral routes of delivery. Nasal route circumvents hepatic first pass metabolism and gut wall enzyme mediated degradation. Nasal route is easily accessible for self-administration without the help of health professionals, and no needle stick hazards are associated with nasal administration. Other advantages of nasal drug delivery systems include rapid onset of action, reduced risk of overdose and improved patient compliance. However, there are several disadvantages of nasal route of administration including impermeability of nasal mucosa to lipophillic and high molecular weight drugs, mucotoxicity associated with long term use of formulation, requirement of expensive delivery device, and dose inaccuracy.
Addisu Yenet, Nisha M. Joseph*, S .Palani, Zelalem Ayenew, Musie Ghezu and Anish Zacharia
School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia
29 May, 2010
18 August, 2010
13 September, 2010
01 October, 2010