NOOTROPIC ACTIVITY OF ISORHAMNETIN IN AMYLOID BETA 25-35 INDUCED COGNITIVE DYSFUNCTION AND ITS RELATED mRNA EXPRESSIONS IN ALZHEIMER’S DISEASEAbstract
Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer’s disease. The present study was designed to investigate the neuroprotective effects of isorhamnetin (IRN) against amyloid beta 25-35 (Aβ 25-35)-induced memory impairment and oxidative damage in rats. Memory task was assessed using Y-arm maze and it revealed the impairment in spatial memory. The IRN treated rats showed improvement in memory task. Aβ 25-35 induced animals also exhibited increase in hydrogen peroxide (H2O2), Monoamine oxidase activity (MAO) and decrease in choline acetyltransferase (ChAT) activity. It also enhanced the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokine, IL-β whereas all these abnormalities were reduced significantly in IRN treated rats showing the neuroprotective effect of IRN against Aβ 25-35 induced Alzheimer’s disease (AD). Thus, IRN may be a potential therapeutic agent for Alzheimer’s disease.
Deivasigamani Asha and Thangarajan Sumathi*
Department of Medical Biochemistry, University of Madras, Chennai, Tamil Nadu, India
30 March, 2016
12 July, 2016
14 July, 2016
01 August 2016