NOVEL COLON SPECIFIC DRUG DELIVERY SYSTEM: A REVIEWAbstract
Now a days, various routes of administration have been explored for the effective delivery of the drug to the target site. The oral route is considered to be most convenient for the administration of drugs to patients. But it has a serious drawback in conditions where localized delivery of the drug in the colon is required. Colon target aimed mainly because of less enzymatic activity, longer transit time so it is suitable to deliver the protien and peptide drugs. It also have drawbacks like less water content, presence of fecal content. Different approaches are designed based on prodrug formulation, pH-sensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The efficiency of drug delivery system is evaluated using different in vitro and in vivo release studies.This review updated the research on different approaches for formulation and evaluation of colon-specific drug delivery systems (CDDS).
Madhu E. Nicholas*, Shanker Panaganti , L. Prabakaran and K. N. Jayveera
Sr. Manager-FR & D, MSN LABORATORIES LTD., Bollaram, Medak, Andhra Pradesh, India
22 May, 2011
10 July, 2011
28 September, 2011
01 October, 2011