NOVEL GENTAMICIN LOADED ELECTROSPUN NANOFIBROUS SCAFFOLDS FOR WOUND HEALING: AN IN- VITRO STUDY
AbstractThe extracellular matrix (ECM) is the backbone in controlling cell behavior in the living organisms during the process of wound healing. The design of a suitable biomimetic nanofibrous scaffold which mimics the properties of natural ECM is a need of present time. In order to create a novel and unique wound dressing material, composite nanoscaled eudragit scaffolds loaded with gentamicin were prepared using the process of electrospinning. The nanofibers were characterized for size, size distribution, surface morphology and surface chemical structures using the Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). In-vitro release of gentamicin was also investigated. In vitro drug release tests confirmed that the nanofibers had pH-dependent drug release profiles. These properties indicate that the drug loaded eudragit nanofibrous scaffold has the potential to be used as a candidate in wound healing treatments
Article Information
20
2230-2233
544KB
1537
English
IJPSR
Charu Dwivedi*, Himanshu Pandey , Avinash C. Pandey and Pramod W. Ramteke
Jacob School of Biotechnology and Bioengineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, 211007, Uttar Pradesh, India
charucas0505@gmail.com
16 February, 2013
15 May, 2013
20 May, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2230-33
01 June, 2013
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