NOVEL NUCLEAR RECEPTOR SUPER FAMILY DATABASEAbstract
The objective of the project is to develop a comprehensive database of Nuclear Receptor (NR) Superfamily-Ligand. Nuclear Receptor Superfamily represents one of the most important families of drug targets in pharmaceutical development. Nuclear Receptor) Superfamily-Ligand is a novel public NR-related chemical genomic database that is primarily focused on the correlation of information between NRs and their ligands. It provides correlation data between NRs and their ligands, along with chemical information on ligands, as well as access information to the various web databases regarding NRs. These data are connected with each other in a relational database, allowing users in the field of NR-related drug discovery to easily retrieve such information from either biological or chemical starting points. NR Superfamily-ligand database includes structure similarity search functions for the NRs and for their ligands. Thus database can provide correlation maps linking the searched homologous NRs (or ligands) with their ligands; we can gain more detailed knowledge about their interactions and improve drug design efforts by focusing on inferred candidates for NR-specific drugs.