NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-AMINO PHENYL-5-METHYL PYRAZOLES AND ITS DERIVATIVESAbstract
Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc. In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 1400C to form analides as intermediate. These intermediates on further reaction with hydrazine hydrate using ethanol as solvent and converted into pyrazoles. The synthesized compounds were characterised by their physical properties, IR, NMR and elemental analysis techniques. The purity of the compounds and completion of reaction was tested by TLC Technique using ethyl acetate and petroleum ether as an eluent (6:4). The antimicrobial activity of synthesized pyrazoles was assessed by Disk diffusion method using gram positive and gram negative strains. The benzoyl and nitroso derivatives were also prepared to confirm the formation of new compounds. The derivative of these compounds also shows good antimicrobial activity.
Priti Warbhe and Reshal Deshmukh*
Department of Chemistry, Shri Shivaji Science College, Congress Nagar, Nagpur, M.S., India
08 July, 2016
22 August, 2016
31 October, 2016
01 January, 2017