NOVEL SYNTHESIS OF OXADIAZOLE DERIVATIVES WITH PYRIMIDINE MOIETYAbstract
A series of different 6-Methyl – 4- aryl -5 – (5-aryl -1,3,4-oxadiazole-2-yl ) -1,2,3,4-tetrahydro pyrimidin-2- (1H) – one / thione ( IIIa-g) have been synthesised fromEthyl – 6- methyl- 2- oxo / thioxo – 4-substituted phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (Ia-g) followed by reaction with hydrazine hydrate in ethanol gave 6 – methyl-2-oxo / thioxo – 4 -substituted phenyl – 1,2,3,4-tetrahydro pyrimidine-5-carbo hydrazide (IIa-g) by means of Microwave irradiation for 2-4 mins and giving excellent yield in short reaction time, are notable advantages of this method. The structure elucidations of all the synthesised compounds have been accomplished by elemental analysis, IR, NMR and Mass spectroscopic method.
Shubhangi P. Waghamale and Pravina B. Piste*
P.G. Department of Chemistry, Yashavantrao Chavan Institute of Science, Satara- 415 001, Maharashtra, India
14 June, 2013
16 July, 2013
22 October, 2013
01 November, 2013