OCULAR DRUG DELIVERY SYSTEM: AN OVERVIEWAbstract
The scientist faced many challenges in Ocular drug delivery system due to unique anatomy and physiology of eye. In ocular drug delivery system there are two types of barriers static and dynamic barrier. Static barriers consist of different segment of eye such as cornea, sclera, retina and blood- retinal barriers. In other way dynamic barriers consists choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution. These both barriers affect the bioavailability of drugs. In recent year some new concept of drug delivery such as iontophoresis, liposome bioadhesive gels, ocular insert, contact lenses etc has been developed to overcome problems associated by static and dynamic barriers These formulation based approaches have high capacity to carry maximum concentration of drug at targeted site of eye.
M. K. Sikandar*, P. K. Sharma and S. Visht
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, NH-58, Bypass Road, Bagphat crossing, Meerut, Uttar Pradesh, India
25 November, 2010
10 March, 2011
16 April, 2011
01 May, 2011