OCULAR EFFECTS OF WATER EXTRACT OF OCIMUM GRATISSIMUM IN RABBITSAbstract
The water extract of Ocimum gratissimum, L Lamiaceae, used in traditional medicine and local food spice, was evaluated for its ocular effect using three ocular parameters, pupil diameter (PD), corneal reflex (CR) and pupillary light reflex (PLR). The phytochemical tests were performed on the pulverized leaves, which were used to ascertain the distribution pattern of some possible bioactive agents responsible for the presumed activity of Ocimum gratissimum. It was also tested for the presence of the following: glycosides, carbohydrates, alkaloids, saponins, flavonoids, tannins and proteins, and the results show the presence of fats and oil, reducing sugar and terpenes> tannins> cyanogenic glycosides> alkaloid and steroidal aglycone, while there were no traces of anthraquinones and flavonoids. The Ocimum gratissimum water extracts caused dilatation of the pupil (3.13%), a mydriatic effect, while the corneal reflex was not abolished, showing a lack of local anesthetic property. However, the pupillary light reflex was present throughout the study.
S. A. Igwe *, M. N. Ezenwaeze, S. O. Nweze and D. J. Ogbonna
Department of Pharmacology and Therapeutics, ESUT College of Medicine, Parklane, GRA, Enugu.
02 May 2021
18 June 2021
05 January 2022
01 February 2022