OPTIMIZATION OF EFFECT OF SUPERDISINTEGRANTS AND SUBLIMING AGENT ON ORODISPERSIBLE TABLET OF ONDANSETRON RESINATEAbstract
Ondansetron is a serotonin 5HT3 antagonist; anti emetic drug. Bitter taste of the ondansetron is a major problem in ensuring patient compliance. Resinates of ondansetron were prepared with Indion 234 and loading process was optimized. A 3² factorial design was used for formulation development of orodispersible tablet of these taste masked resinates. The amount of subliming agent (camphor) and superdisintegrants (sodium starch glycolate) were taken as formulation variables (factors) for optimizing disintegration time, drug release after 15 minutes and friability as dependent or response variables. A mathematical model was generated for each response parameter. The disintegration time was found to linearly increase with the increase in the amount of superdisintegrants. The percentage friability showed no definite relationship with either amount of subliming agent or superdisintegrants. The optimum formulations were chosen by grid search method and their predicted results were found to be in close agreement with experimental findings.
Shridhar Pandya* and Samip Shah
Department of Pharmaceutics, Pioneer Pharmacy Degree College, Vadodara (Gujrat), India
17 March, 2010
09 June, 2010
20 June, 2010
01 July, 2010