ORAL LIPID BASED DRUG DELIVERY SYSTEM: A REVIEWAbstract
In the recent progressive era of pharmaceutical technology, newly investigated most of the drugs come under BCS class II and IV having low solubility as well bioavailability. The drugs are not suitable candidate for the conventional oral delivery of drug. The reason is that the drugs are not able to dissolve in aqueous environment of GI (gastrointestinal) tract. Poor water solubility of drug is challenging to deliver orally. Lipid-based drug delivery systems (LBDDS) is emerging technologies to delivered the drug orally by dissolving, dispersing or encapsulating drugs in lipidic excipient and ultimately results in improvement in bioavailability. This review focus on different types of excipients used in the formulation of LBDDS and digestion and solubilisation of lipid-based formulation in body. This review also focuses on the conversion of liquid dispersion into solid particles of lipid for oral delivery of drug. Different types of lipid-based carriers which are useful for the development of lipid-based delivery are briefly described in this article.
R. Khatri, U. Varia *, H. Katariya and K. Detholia
Department of Pharmaceutics, Smt. S. M. Shah Pharmacy College, Ahmedabad, Gujarat, India.
28 January 2020
26 March 2020
31 March 2020
01 November 2020