ORAL OSMOTIC DRUG DELIVERY SYSTEM: A REVIEWAbstract
Osmosis is physical phenomenon that has been comprehensively studied by scientist in various disciplines of science and engineering. Osmotic devices are the most promising strategy based system for controlled delivery of drug. Conventional drug delivery has little control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in fluctuation in plasma concentration. Drug can be delivered in a controlled over a long period of time by the process of osmosis. Osmotic pump offers much compensation over other controlled release devices i.e. they improve patient compliance with reduced dosing frequency and are easy to formulate and prolong therapeutic effect with uniform blood concentration. They are most reliable controlled drug delivery system is not influenced by different physiological factor with in the gut lumen and the release characteristics can be predicted easily from the properties of the drug and the doses form. In this paper, various type of osmotically controlled pump with basic component and factor affecting has been discussed briefly.
Neetu Khatri *, Sarika Nikam and Ajay Bilandi
Padmashree Dr. D.Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India
18 January, 2016
22 February, 2016
14 March, 2016
01 June 2016