ORAL STRIPS: A NOVEL DRUG DELIVERY TECHNOLOGYAbstract
In the development of a new drug molecule, there are many problems with respect to the dissolution, absorption, and bioavailability. Thus, formulation scientists are majorly focusing on the development of the formulation, which will increase the efficacy of the existing drugs. Oral dispersible films are one of such a novel approach. In given review article, the advantages of oral dispersible films over other oral dosage form and especially over oral dispersible tablets and their applications are discussed. In further part the major advantages regarding first-pass metabolism, disable patients, fast onset, etc., are covered. Furthermore, the overview of all the ingredients used in the formulation of fast dissolving films with the evaluation of these films is discussed in the given review article. Solvent casting, semisolid casting, hot-melt extrusion, solid dispersion extrusion, rolling are the methods which are employed, along with the evaluation parameters like thickness, tear resistance, dryness test of the prepared films are also explored in the article. This review article gives a complete overview of oral dispersible films and their novel approach in the formulation.
A. Karandikar, V. Kedar and C. Surve *
Department of Pharmaceutics, Vivekanand Education Society’s College of Pharmacy, Mumbai, Maharashtra, India.
26 February 2020
25 May 2020
24 November 2020
01 December 2020