OXAZOLINES: THEIR SYNTHESIS AND BIOLOGICAL ACTIVITYAbstract
Heterocylic chemistry have been known for many years but in recent years heteocyclics received great attention. In heterocyclic chemistry oxazoline is one of the most important moiety. Oxazoline moiety shows a wide range of application such as in agriculture industry, pharmaceutical, food industry, natural product, medicine, polymers and various other industries. Oxazoline moiety constitutes the core structure of many biologically active natural compounds. Oxazoline play a major role in medicinal chemistry. Heterocyclic compounds whose containing oxazoline moiety as core structure reported wide range of biological activities such as antibacterial, antifungal, antimicrobial, antioxidant, antipyretic, anti-HIV, anti malarial, anti tumour, anti viral, anti-inflammatory, CNS stimulant activity etc. Oxazolines synthesized by the reaction of various aromatic substitutes like acids, aldehydes, nitriles, azides etc. Synthetic chemist do great work on the synthesis and application part of oxazolines. In this review we have described various synthetic methodologies and their different biological activities reported by organic synthetic chemist.
S. Bansal and A. K. Halve *
School of Studies in Chemistry, Jiwaji University, Gwalior, Madhya Pradesh, India.
21 March 2014
13 June, 2014
15 October 2014
01 November 2014