PATHOGENESIS AND NEURO-PROTECTIVE AGENTS OF STROKE
AbstractStroke remains world’s second leading cause of mortality; and globally most frequent cause of long-lasting disabilities. The ischaemic pathophysiologic cascade leading to neuronal damage consists of peri-infarct depolarization, excitotoxicity, inflammation, oxidative stress, and apoptosis. Despite plethora of experimental evidences and advancement into the development of treatments, clinical treatment of acute stroke still remains challenging. Neuro-protective agents, as novel therapeutic strategy confer neuro-protection by targeting the pathophysiologic mechanism of stroke. The aim of this review is discussion of summary of the literature on stroke pathophysiology, current preclinical research findings of neuroprotective agents in stroke and possible factors that were responsible for the failure of these agents to translate in human stroke therapies.
Article Information
1
3907-16
348
1490
English
IJPSR
Mubarak Muhammad *, Abbas B. El-ta’alu and Muhammad I. Mabrouk
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Science, Bayero University Kano, Nigeria
mubarakmahmad@yahoo.com
10 May, 2016
10 May, 2016
23 September, 2016
10.13040/IJPSR.0975-8232.7(10).3907-16
01 October 2016
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