PELLETIZATION OF LAMOTRIGINE SOLID DISPERSION FOR IMPROVED SOLUBILIZATIONAbstract
Poorly solubility in water of many newly developed high-potential drugs is an obstacle in formulation development. The aim of this study was to increase the solubility of Lamotrigine which is a poorly soluble drug and comes under BCS class-II by using solid dispersion technique. Lamotrigine, PEG 4000 and PVPK-30 solid dispersion was prepared by solvent evaporation method and the formulation was characterized using stability studies, Fourier transform infrared spectroscopy (FTIR) and physical parameters. After checking the preformulation studies and getting satisfactory results pellets were formulated and evaluation was done. Drug entrapment efficiency was more than 98 % which indicates that the pellets formed are good possessing in vitro release of 94.89 & 92.30 % for X1 & X2 batches respectively.